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pathological symptoms in DSS induced rats

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(2016) found that withaferin A is a strong inducer of Nrf2, a transcription factor that controls the production of antioxidant enzymes in response to oxidative stress through activation of the PTEN/PI3K/Akt pathway [146]

Fact: While production drops significantly with age, young adults facing high stress or environmental toxins can experience depleted levels long before they reach their senior years

In some situations, an understanding of the mechanism of toxicity has allowed the development of appropriate treatments or antidotes