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Heidi Seage, Cardiff Metropolitan University An estimated 6% of people in the US and UK suffer from vitamin B12 deficiency

Anyone experiencing symptoms of deficiency should consult their GP for blood tests and appropriate treatment

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In the SURMOUNT-1 trial, people treated with tirzepatide lost up to 22.5% of their body weight over 72 weeks , making it even more effective than semaglutide (NEJM tirzepatide study)

Methylcobalamin B12 is also indicated in those with pernicious anemia, diabetes, neuropathy, heart disease, circadian rhythm sleep disorders, memory loss, depression, fatigue, AIDS, inflammatory bowel disease (IBD), Lyme disease, osteoporosis, tendonitis, psychiatric disorders, Alzheimers disease, liver and kidney disease, and asthma

The need to find new agents for refractory patients has led to the development of mAb-based therapies