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Cytokines as Mediators of Depression Proinflammatory cytokines have attracted significant attention in recent years for their role as mediators of depression

Although the relationship between fat and testosterone levels may be compounded by comorbidities, some research suggests that one of the underlying mechanisms governing this is the coordinated action of E2 activation of estrogen receptor alpha (ER) through increased production of E2 at the level of adipose tissue via testosterone aromatization [148]