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doi: 10.3390/antiox10010017

In this process, PRK/PEKR/eIF2, as the upstream signal of PI3K/AKT activation, can induce the release of DAMPs and activate DCs to participate in the generation of ICD (114)

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4C), these results demonstrate that system x c - activity promotes glucose deprivation-induced cell death through import of L-cystine, depletion of GSH and consumption of NADPH by L-cystine reduction to L-cysteine