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87 Aspartate in cancer TP53 is a gene with the highest mutation frequency in human cancer

However, several drugs, including teprotumumab and BIIB-022, which target IGF-1R, have not shown good therapeutic effects in clinical trials, possibly due to the lack of reliable IGF-1R inhibition biomarkers

Intertumoral Heterogeneity One of the biggest challenges in treating GBM is intertumoral heterogeneity, which refers to the fact that different regions within a single GBM tumor can have different molecular and genetic profiles

A.OBrienJ.BlackS.ChenC.DeCarliC.ErkinjunttiT.et al (2017)

10.1016/j.freeradbiomed.2013.08.139 Free Radical Biol Med

Studies have shown that the TGF-1 signaling pathway is a major player in tissue fibrosis, including IPF (47), and this signaling pathway involves several critical phosphorylation events