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The matricellular phosphorylated glycoprotein osteopontin (OPN) is highly expressed in bone but is also secreted by a variety of cell types including endothelial cells, activated macrophages, leukocytes, and T cells (Murry et al., 1994

In the head-to-head SURMOUNT-5 trial (NEJM, 2025), tirzepatide produced 20.2% body weight loss vs 13.7% for semaglutide at 72 weeks, with similar side-effect profiles

Abbreviation: GSTA4, Glutathione S-transferase alpha 4

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Released Zn 2+ ions thus binds fairly similar domains (Zn-fingers) of other regulatory proteins (transcription factors), which in turn trigger signaling cascades leading to promote the synthesis of proteins useful in facing the effects of metal-mediated oxidative stress [151]