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doi: 10.1016/j.aohep.2019.04.007 20

Neurological manifestations are particularly concerning and may include peripheral neuropathy with paresthesias (tingling and numbness in hands and feet), ataxia, impaired proprioception and vibratory sense, cognitive impairment, memory loss, and in severe cases, subacute combined degeneration of the spinal cord

New information even suggests that the parental nutritional state can impose epigenetic metabolic changes in the fetus (49)

Zaman Javaheri, M.D

Common supplemental doses range from 500 to 1,000 micrograms per day

About 1 in 10 people aged 55 years and over are affected by PN, and the most common cause is diabetes