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Data are all represented as a scatter dot plot with centerline as mean, except for percentages quantifications, which are represented as histogram bars

Under normal metabolic conditions, reactive oxygen species (ROS) maintain cellular homeostasis and signaling [137]

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In vitro , baicalein can act on the early stage of CVB3 infection, reduce the levels of viral RNA, viral protein 3D and viral particles, inhibit CVB3 replication in myocardium, reduce myocardial injury and inflammatory response in vivo , thereby alleviating CVB3-induced myocarditis and improving the survival rate of infected mice

Research published in journals including the Journal of Neurochemistry and Brain Research has examined the molecular mechanisms underlying these effects with Semax-induced upregulation of BDNF, NGF, and TrkB identified as key mediators of the observed neuroprotection, alongside modulation of the inflammatory cytokine cascade in peri-infarct brain tissue

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