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If carbamazepine is not effective or causes side effects, oxcarbazepine or a combination therapy with gabapentin/pregabalin or baclofen can be introduced to improve pain control with fewer adverse effects

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Then in April 2025, Pfizer announced the discontinuation of danuglipron itself after a case of potential drug-induced liver injury was identified in one participant during a dose-optimization study

Muscle Sparing AOD-9604s targeted effect on adipocytes implies minimal influence on protein synthesis, potentially maintaining lean mass during fat loss