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Factors like poor nutrition, chronic stress, exposure to environmental toxins, and illness further deplete these levels, compromising the body's ability to defend against harmful free radicals

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Interestingly, they found aberrations in ROS clearance pathways, including elevated glutathione levels, decreases in mitochondrial superoxide dismutase levels, and glutathione peroxidase 4 mediated lipid oxidative damage

(2011) Antidepressant drugs diversely affect autophagy pathways in astrocytes and neurons--dissociation from cholesterol homeostasis

10.3389/fnagi.2017.00068 222 PimentelL

(2011) AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1