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Restoration of glutamate homeostasis by stimulating cystineglutamate exchange with N -acetylcysteine restores the capacity to induce synaptic plasticity and reverses the drug-induced changes in spine morphology

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However, dependent upon the degree of lyonization, and the degree to which the abnormal G6PD variant is expressed, the mean red blood cell enzyme activity in females may be normal, moderately reduced, or grossly deficient

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For patients who do not heal after 4 to 8 weeks, an additional 4 to 8 weeks of treatment may be required to achieve healing