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The family of NF-B consists of five structurally similar members, involving p50/p105 (NF-B1), p52/p100 (NF-B2), RelA (p65), RelB, and c-Rel (Liu et al

Moreover, iron-induced oxidative damage compromises the BBB, allowing harmful substances to infiltrate the brain and intensify neuroinflammation, creating a vicious cycle of neuronal dysfunction and degeneration [85,101,102]