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NAC has also been used in combination with other potential neurotherapeutics including minocycline [20,21,22,23,24,25,26], topiramate [17], selenium [27], sulforaphane [28], levetiracetam, and gabapentin [29] and 2,4-disulfonyl alpha-phenyl tertiary butyl nitrone [30] with suggestion of synergy

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In line with previous reports 24 , we observed that CHAC1 expression was selectively upregulated by cystine deprivation and by the System Xc inhibitor Erastin, but not by other stressors such as dual BCL-2/BCL-XL inhibition, direct GPX4 inhibition, or serum/selenium withdrawal ( Figure Sup

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It demonstrates unusual stability, remaining intact in human gastric juice for more than 24 hours