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KLF2 inhibits cancer cell migration and invasion by regulating ferroptosis through GPX4 in clear cell renal cell carcinoma

PPV was 0.72 0.05, NPV was 0.93 0.02, Sensitivity was 0.79 0.08, Specificity was 0.90 0.03, F1 Score was 0.75 0.05, AUROC was 0.92 0.02, and Matthews Correlation Coefficient (MCC) was 0.67 0.07

Importantly, glutathione (GSH) acts as an essential cofactor for the enzyme family glutathione peroxidases (GPx), which catalyze the reduction of hydrogen peroxide and lipid hydroperoxides into water and their corresponding alcohols

But people should be cautious about taking supplements in general, particularly glutathione

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Interrupting glycolysis is highly valued as a therapeutic strategy, because glycolytic disruption is generally tolerated in mammals