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Incidence of brain metastases after trimodality therapy in patients with esophageal or gastroesophageal cancer: implications for screening and surveillance

Additional risk factors include having your gut operated on, pancreatic insufficiency, small intestinal bacterial overgrowth (SIBO), parasite infections, and certain autoimmune disorders

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Digestive efficiency, gut health and individual metabolism all influence oral bioavailability

Curcumin also reduces BBB disruption by modulating matrix metalloproteinases and tight junction proteins (Yang et al., 2007)