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Options include Chimeric antigen receptor T-cell therapy (CAR-Tcell), a form of adoptive T-cell transfer, cancer vaccines, monoclonal/polyclonal or therapeutic antibodies, oncolytic virus therapies, immune-system modulators, cytokine therapies, and immune checkpoint inhibitors which are negative regulators of T cells [14], as shown in Fig

Nowadays we can understand that sex, age, race and ethnicity, in the context of socioeconomic status and lifestyle (tobacco, alcohol, education, physical exercise, unbalanced diet, etc.) impacts directly in its prevalence [7, 8, 10, 27 36]

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The researchers reported increased synthesis and mRNA expression of neurogenic differentiation markers including Nestin, GAP43, Tubulin III, and Doublecortin