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C.AmorimF

DOI:10.3389/fphar.2021.627533 10.3389/fphar.2021.627533 Gojkovic.S, Krezic.I, Vranes.H, Zizek.H, Drmic.D, BPC 157 Therapy and the Permanent Occlusion of the Superior Sagittal Sinus in Rat: Vascular Recruitment

(2024) and Kee et al

(Philos.) 57 , 686691 (2019)

This activation converts pro-interleukin-1 (pro-IL-1) and pro-interleukin-18 (pro-IL-18) into their active forms, which are subsequently released extracellularly, initiating sustained inflammation that disrupts neural circuits and promotes both seizures and depressive behaviors