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Both arginase and NO synthase reactions crosstalk with other RBC metabolic pathways, such as glutathione homeostasis and heme synthesis of haemoglobin [7]

However, the mechanical properties of previously reported hydrogels for chondrogenesis based on natural or synthetic polymers, such as alginates, chitosan, or polyethylene glycols (PEG), were considerably lower than those of natural cartilage tissue 54,55,56