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Moreover, the tumor microenvironment (TME) in HCC is enriched with M2-polarized tumor-associated macrophages (TAMs), a dominant immunosuppressive population that promotes NK cell dysfunction and exhaustion [5, 11, 12]

In the inhibitor experiments, blocked transporters are shown above the bar, active transporters within the bar

Small molecules directly targeting the clock proteins offer the potential to directly manipulate endogenous circadian rhythm to improve clock-regulated output processes, as well as to treat diseases associated with clock misalignment (for a comprehensive review on the topic see 135

doi: 10.1128/MCB.01204-10

Y., Nikolic-Paterson, D

Phase-separating peptide coacervates with programmable material properties for universal intracellular delivery of macromolecules