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However, a recent study has shown that in order to lethally impact the peroxidation process, PUFAs must be activated and integrated into phospholipids (PLs), a form of membrane lipid, and that free fatty acids cannot trigger ferroptosis

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2 Contribution of Ferroptosis in Cardio-Cerebrovascular Disease As the maintenance of cardio-cerebrovascular homeostasis depends on CD and cell renewal, excessive cell loss will contribute to the occurrence of many CCVDs (Lu et al., 2020)