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Pulmonary infection have to be ruled out by endotracheal aspirate or BAL

[11] In summary, while alpha-lipoic acid is generally compatible with many medications, it can amplify blood sugar-lowering drugs and alter thyroid hormone activity, among other interactions, so proactive monitoring and consultation with healthcare professionals are essential

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An orange precipitate formed that collected by filtration

(Zhao et al., 2020) demonstrated that adding 20 % ( w / v ) sucrose or trehalose may stabilize nanoparticles' size and mRNA delivery efficiency in vitro, but the lyophilized nanoparticles did not exhibit efficiency in vivo