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10.3945/ajcn.115.124081 299 ZhangY.LinC.ZhangL.CuiY.GuY.GuoJ.et al (2015)

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2021;81(2):355-369.e310

Since SOD converts superoxide to HO, its upregulation can elevate HO levels, which not only acts as a vasodilatorpotentially explaining the increased basal coronary flow observed in diabetic and diabetic-CKD animalsbut also leads to greater oxidative stress when GPX-mediated detoxification is compromised, resulting in increased tissue damage [44]