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The peroxisome proliferator-activated receptor (PPAR) / agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells The aim of this study was to investigate whether the peroxisome proliferator-activated receptor (PPAR)/ agonist GW501516 could prevent IL-6-induced insulin resistance in human hepatic HepG2 cells

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These results align with recent studies showing that GLUT1OE is associated with increased memory formation in CAR T cells and enhanced antitumor potency in mouse models of acute lymphoblastic leukemia (ALL), renal cell carcinoma (RCC), and glioblastoma (GBM) 51

Am J Med Genet B Neuropsychiatr Genet 135: 59