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The positive transcriptional regulatory factors CLOCK (CLK) and CYCLE (CYC) form heterodimers that lead to the transcription of the negative regulators PERIOD (PER) and TIMELESS (TIM) via binding to E-boxes in their promoters 7,8

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Mangiferin prevents myocardial infarction-induced apoptosis and heart failure in mice by activating the Sirt1/FoxO3a pathway

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doi: 10.1007/s00262-014-1594-z 293 RiordanJDKengVWTschidaBRScheetzTEBellJBPodetz-PedersenKMet al