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It has been reported that IGFBP-3 binds to a nuclear receptor, 9-cis retinoic acid receptor-alpha (RXR-), which interacts with peroxisome proliferator activated receptor-gamma (PPAR-), a nuclear protein involved in the regulation of glucose and lipid metabolism [175, 176]

Consult primary literature for compound-specific findings

[ 28 , 29 , 30 ] MOTS-c can be used for the benefit of weight loss, improving insulin sensitivity, energy production, neuro-protection, and longevity

39 , e00210-19 (2019)

While some places might market it for general energy boosts or weight loss, if your B12 levels are already normal, there's little scientific proof that these injections will give you a significant energy rush or help you lose weight

Now, to understand why this might matter, we need to zoom in on an underappreciated problem in human metabolism