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Although not all HU patients will experience gout flares, HU is a primary risk factor for gout, and both conditions lead to systemic metabolic alterations underlying metabolic disorders

These molecules can be receptors/transporters substrates, substrate derivatives, substrate-binding moiety fragment molecules, antibodies or antibody-binding fragments against the receptors/transporters

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Meanwhile, CYP2E1-mediated oxidation and sulfation in drug metabolism are higher than that of non-obese individuals (Van Rongen et al., 2016)

Unmet need in rheumatology: reports from the advances in targeted therapies meeting, 2023