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2374-C TARGETING CHRONIC VEGF-C SIGNALING MITIGATES DISEASE PROGRESSION IN NON-ALCOHOLIC STEATOHEPATITIS Jason Eng 1,2 , Seock-Won Youn 1 , Bhairavi Swaminathan 1 , Rahul Vadakath 1 and Jan Kitajewski 1,3 , (1)University of Illinois at Chicago, (2)Cleveland Clinic Foundation, (3)University of Illinois Cancer Center Background: The sinusoidal endothelial cells (LSECs) are critical regulators of homeostasis within the liver

Evidence from a recent study demonstrates that DHA effectively attenuates profibrotic cytokine signaling in hepatic stellate cells (HSCs) by inhibiting TGF-1induced Smad2/3 phosphorylation and downregulating the expression of classical fibrogenic markers, including -SMA and collagen 1(I), in a dose-dependent fashion (Figure 1B) ( Numerous animal studies have consistently demonstrated DHAs potent capacity to suppress hepatic inflammation

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doi: 10.1155/2010/535612 114 YuanJLiLIWangZSongWZhangZ