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The valproate effect was traced to inhibition of PLC which forms DAG and IP3 and would hamper downstream pkc activity (Tokuoka et al., 2008)

Zeng, C., Chen, Y., Das, A

Comparison of different Organic solvents on antioxidant activity of Astaxanthin extracted from Hematococcus pluvialis

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doi: 10.1016/j.ceca.2011.04.007

Localized iron leakage across a compromised BBB may generate ROS in affected regions, which further damages BBB integrity, creating a detrimental feedback loop