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2 IV Acetadote protects liver cells in 2 ways: It helps replenish glutathione It binds to and removes NAPQI Return to top The maximum adult therapeutic dose of acetaminophen is 4 grams/24 hours 3 The maximum dose for children less than 12 years is 75 mg/kg 4 Acute overdose is defined as ingestion of 150 mg/kg or 12 grams/24 hours 4 Four stages of acetaminophen overdose 5 Return to top When time is liver, timing is critical Treatment Recommendations The following recommendations are related to acute acetaminophen ingestion

ABBREVIATIONS ABC ATP-binding cassette transporters APK adenosine-5-phosphosulfate kinase APS adenosine-5-phosphosulfate BAT or BASS bile acid transporter BCAT branched-chain amino acid aminotransferase CHS chalcone synthase CF conjugated flavonoids CLT chloroquine-resistance transporter (CRT)-like transporters Cys cysteine -EC -glutamylcystein GGT gamma-glutamyl transpeptidase GSH glutathione GSL glucosinolates GST glutathione-S-transferase GTR glucosinolate transporter H 2 S hydrogen sulfide IMPI isopropylmalate isomerase IPM-DH isopropylmalate dehydrogenase Leu leucine MAM methylthioalkylmalate synthase MATE multidrug and toxic compound extrusion Met methionine MDR multidrug resistance family of transporters MRP multidrug resistance-associated protein MTOB 4-methylthio-2-oxobutanoate NRT/PTR nitrate and peptide transport family OAS O -acetylserine OASTL O-acetylserine (thiol)lyase PAs proanthocyanidins PAP 3-phosphoadenosine 5-phosphate PAPS 3-phosphoadenosine-5-phosphosulfate PAPST1 3-phosphoadenosine-5-phosphosulfate transporter PC phytochelatins PDR pleiotropic drug resistance PSK disulfated pentapeptide phytosulfokine PSY1 peptide containing sulfated tyrosine 1 RGFs root growth factors (peptides containing sulfated tyrosine) S sulfur SAM S-adenosylmethionine SAMT SAM transporter SMM S-methylmethionine SLC13 sodium/sulfate co-transporter SLC26 sulfate/anion (A - ) exchanger SLIM1 transcription factor Sulfate Limitation 1 SOT sulfotransferase STAS domain found in sulfate transporters with a significant similarity to bacterial anti-sigma factor antagonists SULTR plant sulfate transporters SURE sulfur-responsive element in the promoters of genes TGN trans Golgi network TPST tyrosylprotein sulfotransferase tt transparent testa mutants Val valine YCT1 cysteine transporter 1MO-I3M 1-methoxy-indole-3-ylmethyl-glucosinolate 4MO-I3M 4-methoxy-indole-3-ylmethyl-glucosinolate

Academic Emergency Medicine

Understanding Glutathione and Its Importance It is a natural antioxidant found in every cell of the body

Catalase levels in the sample were determined by comparing the absorbance at 653 nm to that of a catalase standard