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Leucovorin, also known as folinic acid, is a form of vitamin B9 (also known as folate) that is used to treat certain types of vitamin B9 deficiency that are usually caused by cancer chemotherapy

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Thus, folic acid improves eNOS coupling and function, supporting NO production and protecting brain endothelial function

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All these changes contribute to a decreased absolute value of the resting membrane potential, reduced atrial voltage, and delayed excitation conduction [27]

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