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Oxidative stress: a key modulator in neurodegenerative diseases

Results Animals and food intake At the start of the study, mean body weight of the animals was 243 g

reported that inhibition of the Xc- transport system using sulfasalazine, while ineffective as a monotherapy, was highly effective to eliminate AML cell lines when combined with Buthionine sulfoximine (BSO), an inhibitor of glutamyl cysteine synthetase, the first enzyme in the synthesis of GSH

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This suggests that NCOA4 in AD may be translocated to the cytoplasm, where it could induce the degradation of ferritin and increase sensitivity to ferroptosis [41]