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When a patient on a stable transdermal estradiol regimen cannot fill her prescription because patches are on backorder, the prescriber faces a clinical decision: switch to an oral formulation (with a different risk profile), switch to a different delivery system the patient hasnt used before, or consider a compounded transdermal estradiol preparation that delivers the same active ingredient through the same route

It is particularly relevant for patients whose training produces diffuse connective tissue stress across multiple joints simultaneously, which is common in athletes running compound movements at high volumes

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