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Initially, research on pancreatic cancer revealed that blocking HGF/c-MET reduced TGF- release from cancer cells, leading to an increase in cytotoxic T-cell invasion, which culminated in the demise of cancer cells within the tumor [93]

These cells are crucial for maintaining the balance of tissues when faced with various systemic injuries such as infections and traumatic stress [72]

197 In conclusion, paracrine FGF21 can delay aging through multiple pathways

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