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Thus, it should be possible to find compounds that inhibit TGR but have much less effect on the mammalian enzymes

Schultz, W., Dayan, P

Chronic CS exposure causes pulmonary endothelial dysfunction in animal models, healthy young smokers, and chronic smokers with COPD [98, 99]

In complex environments like tumors, AA starvation could affect cellular physiology in a differential way: rapidly proliferating cells, including malignant cells, might be forced out of the cell cycle by neighboring cells expressing AA-degrading enzymes (combined with the effects of local nutrient consumption and reduced perfusion in solid tumors)