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B12 also downregulated CSF2 ( P = 0.0071) and CXCL10 ( P = 0.0205) in leukocytes from impaired individuals, although these genes were not differentially regulated when compared to the non-impaired group

Clinical evidence indicates that elevated systemic oxidative stress biomarkers are associated with cardiovascular disease risk (85)

Prevention of heart failure by antihypertensive drug treatment in older persons with isolated systolic hypertension

Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARalpha in primary human hepatocytes

We included a 10x-histidine tag (his-tag, Bba_K844000) in our constructs, so that we could purify the expressed proteins