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Under physiological conditions, autophagy plays a protective role in maintaining cellular homeostasis and may induce cell death only when it is excessively activated or when the autophagic flux is blocked

117 Several studies have provided evidence that a cross-talk among different ROS sources occurs in the vasculature, in particular between the Nox and mitochondria

Concerning oxaliplatin resistance, in support of previous results 45 , the intracellular accumulation of oxaliplatin was significantly reduced in HCT116/OxR cells as compared to the parental cell line

Thus, dietary supplements containing much lower doses may not have any influence on the studied subjects

Finally, we review current preclinical efforts to target FSP1, with emphasis on small-molecule inhibitors, mechanism-based combinations, candidate biomarkers, and major translational challenges