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however, in phase 1 clinical trial, BIIB078 failed to exert meaningful effects on CNS pathologies and had no significant impact on neurofilament levels but paradoxically increased inflammatory marker CCL26, and its development has been discontinued (van den Berg et al., 2024

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Breakthrough computational tools such as AlphaFold3 169,170 and RoseTTAFold All-Atom 171 have opened new opportunities for GPCR-targeted drug discovery, greatly advancing structure-based drug development

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