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Remarkably, as seen in Fig 6D, the HP-INHIB-4488 inhibitor led to up-regulation of proinflammatory genes over the reference control, specifically at the basal (nonstarved) conditions and at 4 and 24 h of starvation, whereas the expression of ER stressassociated genes was up-regulated mostly at 24 h

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Some small molecule compounds that can induce tumor cell ferroptosis such as SRF and SAS have been used in clinical studies