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doi: 10.1080/10408398.2021.1987858 109

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Deoxycholic acid (DCA), a secondary BA, inhibits the plasma membrane Ca + ATPase (PMCA), suppressing Ca + -NFAT2 signaling and reducing cytotoxic molecules such as IFN-, TNF-, and granzyme B (GzmB), potentially impairing ICI efficacy when intratumoral DCA is high ( + T cell activation and cytokine production, and has been associated with improved ICI response in non-small cell lung cancer, possibly via enhanced memory CD8 + T cell formation ( + T cell infiltration and favorable outcomes ( + T cell infiltration and limits HCC progression ( The microbiota shapes the BA pool and influences CD8 + T cell function

[DOI] [PMC free article] [PubMed] [Google Scholar] Alexander SPH, Cidlowski JA, Kelly E, Marrion NV, Peters JA, Faccenda E et al (2017a)