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Acknowledgements This project was supported by the National Natural Science Foundation of China (82272232, 82170775, 82370765, 82270802, 82100806, and 82300766) and the Open Project of Hubei Key Laboratory (2023KFZZ009)

Maiese K, Chong ZZ, Hou J, Shang C (2009) The vitamin nicotinamide: translating nutrition into clinical care

Levine GN, Frei B, Koulouris SN, Gerhard MD, Keaney JF, Vita JA

B.ThorpeK.ChenY.et al

Through personalized medical guidance and lifestyle adjustments, individuals like Sarah can unveil the silent impact and take steps toward improved health and well-being

2-HG transport into T cells is facilitated by the sodium-dependent dicarboxylate transporter (SLC13A3), altering its effector function and cell proliferation