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Additionally, the median age of children with poor treatment responses (7 years, IQR 610) was significantly older than that of children with more favorable treatment responses (5 years, IQR 48, p = 0.03)

Multi-omics analyses of airway host-microbe interactions in chronic obstructive pulmonary disease identify potential therapeutic interventions

reported that short-term Anakinra therapy (12 months) only improved ACR20 and ACR50 response rates compared to placebo, with no significant differences in other efficacy endpoints (Scott et al., 2016)