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Morning administration in a fasted state is the most commonly cited timing because endogenous fat mobilisation is naturally elevated after an overnight fast, theoretically amplifying the lipolytic signal from the peptide

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Given this critical role of GH in adjusting metabolism to the fasting condition, it is plausible that the metabolic effects of GH are required for optimal linear growth of the human fetus and that this explains marginal effects on linear growth of the human fetus

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