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J.BlandJ

Crit Rev Microbiol

Vitamin B6 also helps produce neurotransmitters (like GABA, dopamine, serotonin) that influence mood and cognitive function, and regulates the immune response by helping inhibit proinflammatory cytokines

128 Additionally, thalidomide inhibits M1 macrophage polarization by targeting the transcription factor IRF5, reduces the release of inflammatory signals, significantly reduces the secretion of the proinflammatory cytokines IL-12 and IFN-, and promotes intestinal mucosal healing