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FIGURE 11 Ferroptosis is characterized by the iron-dependent accumulation of lipid ROS and is morphologically and mechanistically distinct from other programmed cell death pathways (Dixon and Stockwell, 2014

This probe showed covalent labeling of GCLM and dose-responsive competition of this labeling by EN25 (Fig

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At the mechanistic level, intracellular iron availability is coordinated by HIF signaling together with iron regulatory proteins (IRPs) (70), linking oxygen sensing to epithelial redox vulnerability