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The fact that the gut microbiota are key regulators of immune function and inflammatory responses, it is likely that a change in the composition of the gut microbiota during aging plays a role in the gradual activation of the immune system and consequently inflammaging (Prenderville et al., 2015), possibly via an impact on intestinal permeability

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ChengZJiangXPansuriaMFangPMaiJMallilankaramanKet alHyperhomocysteinemia and hyperglycemia induce and potentiate endothelial dysfunction via mu-calpain activation

AJP Ren Physiol [Internet], 302 (2012), pp