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Delayed-Release Oral Mesalamine at 4.8 g/day (800 mg tablet) for the Treatment of Moderately Active Ulcerative Colitis: The ASCEND II Trial

Meanwhile, the results of Western blot assay showed that the protein expression levels of Cyclin A2 , Cyclin E2 , c-MYC , Cyclin D1 and CDK2 were significantly increased in the RRM2 overexpression group, and Cyclin D1 , Cyclin E1/E2 and Cyclin A2 are important regulators driving the cell cycle process, and their high expression is often associated with the acceleration of G1/S phase transition

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Any changes in physical or behavioural state were recorded in the daily reporting documentation and relayed to the veterinary department if not already present