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( M ) MDA level was measured in the cortex and hippocampus, respectively ( n = 5)

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(The Emiratis had agreed to regulate the drug study.) The participants underwent a battery of physical exams, and then were put on personalized protocols, prescribed by doctors, before receiving their first pills and injections

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Of interest, treatment of aged rats with IGF-I was shown to upregulate eNOS and improve bioavailability of NO [295], and in vitro experiments in cultured endothelial cells demonstrated that IGF-I treatment reduce ROS production and upregulate eNOS [294]