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Furthermore, NAC (anti-oxidant via GSH upregulation) treatment increased GSH levels and clearly reduced lipid peroxidation, further supporting the notion that not only GPx4 levels but also GSH levels are a critical determinant for regulating lipid peroxidation and subsequent ferroptosis (Supplementary Fig

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Deficiency of lipin-1, a lipid metabolism-related molecule, downregulates FAO by inhibiting PGC-1/PPAR-mediated CPT1A/hepatic nuclear factor 4 alpha (HNF4) signaling and upregulates sterol-regulatory element binding protein (SREBP) to promote fat synthesis, thereby causing renal tubular epithelial cell damage and exacerbating fibrosis [52]

Blood Thinners (e.g., Warfarin): Due to its potential to improve blood flow, astaxanthin may have a mild blood-thinning effect, which could interact with anticoagulant medications

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doi: 10.3390/cancers11070931