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Oral BMS treatment of animals markedly attenuates epidermal thickening, keratinocyte hyperproliferation, and neutrophil infiltration in DKO* mice, while restoring GPX4 and reducing 4-HNE accumulation

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found that monoclonal antibodies derived from mice are cleared by the human immune system, which limits the efficacy of nanocarriers conjugated to this antibody[195]

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