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In obesity and metabolic syndrome, aromatization of androgens in adipose tissue and lower sex hormonebinding globulin (SHBG) raise bioavailable estrogen (83), linking metabolic dysfunction to hormone-driven tumorigenesis

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Given the FoxO1 ablation induced -cell dedifferentiation and caused hyperglycemia under physiologic stress 22 , we determined whether LOsG/ROS stresses decrease FoxO1 expression and thus induce -cell dedifferentiation

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